None listed
Conditions
Interventions
placebo group:placebo
intervention group:protocatechuic acid
Sponsors
Sun Yat sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age of 18-70 years old, both sexes; 2. Mild or moderate active UC, with modified Mayo score of 3-10 and endoscopic findings score =2; 3. New or recurrent ulcerative colitis who have been treated with 5ASA orally for 2-3 weeks and have agreed to maintain their current medication and dose throughout the study; 4. hemoglobin >10 g/dl 5. Voluntarily participate in the study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Receiving any other kind of anti-UC drug other than 5ASA; 2. Severe UC (Mayo score 11-12) or severe UC according to modified Truelove and Witts criteria; 3. Serious chronic diseases such as proctitis, cancer, diabetes, cardiovascular and cerebrovascular diseases, liver and kidney insufficiency, kidney or liver disease, chronic pancreatitis, gallstones, infectious diseases, sepsis or pneumonia; 4. Anemia (Hb < 10g/dl), leukopenia, thrombocytopenia, abnormal coagulation; 5. Pregnant or lactating women; 6. Relatives of researchers or research administrators; 7. Have a relative enrolled in the study; 8. Concurrently participating in any other clinical intervention trial; 9. Deafness, dementia, or inability to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical remission rate;Clinical effective rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fecal gut microbiota ;Serum inflammatory index;IBDQ-32;Dietary questionnaire;Exercise Scale; | — |
Countries
China
Contacts
Public ContactDongliang Wang
Sun Yat-sen University
Outcome results
None listed