helicobacter pylori infection
Conditions
Interventions
Triple therapy group:Vonoprazan 20mg bid with furazolidone 100mg bid and amoxicillin 750mg bid for 7 days
Quadruple therapy group:omeprazole 20mg bid with bismuth 200mg bid, amoxicillin 1000mg bid and clarithromycin 500mg bid for 14 days
Sponsors
Qingyuan People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: aging 18 to 70 years, having Hp infection confirmed by a positive result of 13C urea test and meeting the indications for H. pylori eradication
Exclusion criteria
Exclusion criteria: History of receiving H. pylori eradication therapy; History of esophageal or gastric surgery; peptic ulcer, gastrointestinal bleeding, gastric cancer and gastric MALT lymphoa; usage of antibiotic, bismuth or any Chinese traditional medicine within 4 weeks and Vonoprazan, PPI, H2-Receptor Antagonists within 2 weeks; severe cardiac, pulmonary, renal, hepatic and immune insufficiency; pregnancy or breast feeding; psychiatric diseases and disability of communicating; allergy to any of the study drugs; G-6-PD deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate of Hp infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| the incidence of adverse effecet; | — |
Countries
China
Contacts
Public ContactPeng Tieli
Qingyuan People's Hospital
Outcome results
None listed