Postoperative delirium
Conditions
Interventions
POD group/Non-POD group:No
Sponsors
Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Age =65 years old; ASA grading ?~? showed no obvious abnormality in organ function. Preoperative MMSE score =24; No contraindications for subarachnoid-epidural block anesthesia; Sign informed consent;
Exclusion criteria
Exclusion criteria: Preoperative MMSE score < 24; A past history of serious mental or neurological illness; Abusing drugs or psychotropic drugs, using steroids, hormones and other drugs for years; Patients had stage ?-? hepatic encephalopathy before surgery. Recent history of major surgery; Severe intraoperative bleeding and postoperative complications occurred. Patients with severe vision and hearing impairment who are unable to cooperate with the test; Patients who have contraindications to combined subarachnoid and epidural block and cannot undergo such anesthesia;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Macrophage migration inhibitor factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| amyloid beta;tau protein; | — |
Countries
China
Contacts
Public ContactXian Xian
Department of Anesthesiology, The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed