Postoperative gastrointestinal dysfunction
Conditions
Interventions
Control group:Normal saline was pumped,PCIA (sufentanil 3µ g/kg)
Intervention group 1: Esketamine group1(Preoperative: 0.25 mg/kg, maintained at 0.15 mg · kg-1 · h-1, PCIA (sufentanil 2 µ g/kg+esketamine 1.5 mg/kg)
Intervention group 2: Esketamine group2 ((Preoperative: 0.125mg/kg, maintained at 0.075 mg · kg-1 · h-1, PCIA (sufentanil 2 µ g/kg+Esketamine 0.75mg/kg))
Sponsors
The Affiliated Cancer Hospital of Guizhou Medical University
Eligibility
Sex/Gender
Female
Age
25 Years to 65 Years
Inclusion criteria
Inclusion criteria: ? Age 25-65 ?American Society of Anesthesiologists grading I and II ?Body Mass Index 18-30kg/m2 ? Planned open surgery for cervical cancer patients under general anesthesia ? Surgical duration 2.5-4.5 hours ? Patient is willing to use patient controlled intravenous analgesia ? Sign informed consent form
Exclusion criteria
Exclusion criteria: ? Patients with known gastrointestinal motility disorders ? Previous history of major abdominal surgery (excluding cesarean section, appendix and cholecystectomy) ? Severe liver and kidney dysfunction ? Untreated or poorly controlled hypertensive patients (resting systolic blood pressure = 180mmHg and/or diastolic blood pressure = 100mmHg) ? Patients with hyperthyroidism without treatment or under treatment (pulse rate>90 times/minute, basal metabolism rate>20%, emotional instability, insomnia, weight loss and other symptoms) ? Patients with obvious ischemic heart disease ? Patients with elevated intraocular pressure, intracranial pressure, or mental illness ? Individuals who are allergic to esketamine or other anesthetics ? Patients with urinary tract obstruction, asthma, or epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative gastrointestinal dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily I-FEED score for 7 days after surgery;Daily visual analogue scale (VAS) rest and exercise scores, as well as number of analgesic pump presses, 7 days after surgery;;The dosage of opioid drugs and the dosage of esketamine;;Rehabilitation progress indicators: first exhaust, defecation time, first oral intake time, and first time out of bed activity time;;The incidence of respiratory depression, hypotension, vomiting, nausea, and itching within 24 and 48 hours after surgery.;The incidence of multiple dreams, nightmares, hallucinations, mental disorders, restlessness, difficulty in orientation, blurred vision, tachycardia, and salivation within 24 and 48 hours after surgery.; | — |
Countries
China
Contacts
Public ContactLi Jimei
The Affiliated Cancer Hospital of Guizhou Medical University
Outcome results
None listed