PCOS
Conditions
Interventions
OC preconditioning group:After using OC(yasmin) to resist androgen for 3 cycles before entering the ovulation induction cycle
control group:entering the ovulation induction cycle directly without resist androgen
Sponsors
Women's Hospital School of Medicine Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1) Age: 20-40 years old, accepting IVF/ICSI for pregnancy; 2) 18.5Kg/m2=BMI<24Kg/m2 3) Patients with polycystic ovary syndrome following hyperandrogens; 4) Currently or in the past 3 months, have not participated in other research projects; 5) Sign informed consent form;
Exclusion criteria
Exclusion criteria: 1) Other endocrine diseases accompanied by hyperandrogenism, such as Cushing's syndrome, congenital adrenal hyperplasia, ovarian or adrenal tumors, as well as other inflammatory diseases, autoimmune diseases, malignant tumors (such as Crohn's disease, ulcerative colitis, rheumatoid arthritis, systemic lupus erythematosus, hypertension, benign or malignant hematological diseases, etc.); 2) Other endocrine diseases such as neurological and psychiatric diseases, coronary heart disease, adrenal diseases, thrombotic diseases, pituitary microadenoma, thyroid dysfunction, etc.; 3) Ovarian cysts, uterine fibroids (diameter =4cm), adenomyosis, severe hydrosalpinx, severe endometriosis (stage III-IV); 4) History of ovarian or uterine tumor surgery and other major organ surgeries; 5) Severe intrauterine adhesions; 6) Oral contraceptives, glucocorticoids, immunosuppressants, antihypertensive drugs, lipid-lowering drugs, and other anti-androgenic drugs taken within the past 3 months; 7) Testicular biopsy for sperm retrieval for ICSI; 8) Smokers and alcohol drinkers; 9) Contraindications to oral contraceptives; 10) Other situations deemed inappropriate by the researcher and unable to participate in follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reproductive hormone tests;BUS;Pregnancy-related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete blood count;Coagulation function;Thyroid function;Liver and kidney function;Blood lipid test;OGTT-IRT; | — |
Countries
China
Contacts
Public ContactGuofang Feng
Women's Hospital School of Medicine Zhejiang University
Outcome results
None listed