Optic nerve related diseases
Conditions
Interventions
optic neuritis:N/A
Non-arteritis ischemic optic neuropathy:N/A
optic nerve atrophy:N/A
primary open-angle glaucoma:N/A
Sponsors
The First Affiliated Hospital of Hainan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. ON: (1) Acute or subacute vision loss with or without eye rotation pain; (2) The pupil is dilated, and the relative pupillary afferent disorder is positive; (3) The optic papilla edema is congested or normal; (4) The visual field defect was consistent with ON; (5) P100 latency is prolonged or amplitude is correspondingly reduced so that no corresponding waveform occurs; (6) There is no clinical and laboratory evidence of retinal diseases and other diseases of the eye and nervous system that cause acute visual loss. 2. NAION: (1) moderate to severe visual impairment, which is common in middle-aged and elderly patients, and can have cardiovascular diseases such as diabetes and hypertension; (2) Optic disc edema, pale white; (3) In the visual field, there is a sector defect connected with the physiological blind spot. 3. Optic nerve atrophy: (1) Have a history of ocular trauma, accompanied by varying degrees of visual loss; (2) The optic disc boundary is clear or blurred, pale or pale; (3) Pupils dilate, and light reflex disappears or becomes dull; (4) VEP examination showed that the latency of P100 wave was prolonged and the amplitude was decreased; (5) Fundus fluorescein angiography showed low fluorescence in the optic disc. 4. POAG: (1) There may be eye dilation, iris and blurred vision; (2) The room angle is open, and the IOP is greater than 21mmHg; (3) Fundus examination showed optic disc damage or RNFL defect; (4) Visual field examination showed paracentral scotoma, nasal ladder, arc-shaped scotoma, circular scotoma, and tubular visual field.
Exclusion criteria
Exclusion criteria: (1) Patients with unclear diagnosis; (2) Age3D; (4) Previous history of intraocular surgery or eye injury; (5) Unreliable Humphrey perimetry (false negative rate and false positive rate>15%, fixation loss rate>20%); (6) Patients with blurred refractive media are defined as having signal intensity<6 or poor OCT scanning quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Best-corrected visual acuity;vessel density;Perfusion density; | — |
Countries
CHINA
Contacts
Public Contactliu liang
The First Affiliated Hospital of Hainan Medical College
Outcome results
None listed