gastrointestinal endoscopy
Conditions
Interventions
Esketamine 0.1mg/kg +Ciprofol group:Ciprofol combined with Esketamine sedation
Esketamine 0.2mg/kg +Ciprofol group:Ciprofol combined with Esketamine sedation
Esketamine 0.3mg/kg +Ciprofol group:Ciprofol combined with Esketamine sedation
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients who receive painless gastrointestinal endoscopy; 2. Age= 60 years old, Both men and women; 3.BMI:18-30kg/m²; 4.ASAI~III; 5.Ability to read and understand; Informed and willing to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Severe cardiovascular and cerebrovascular diseases, lung, kidney and liver diseases or systemic inflammatory diseases; 2. Patients with hyperthyroidism, glaucoma, and patients at risk of increased intracranial pressure; 3. Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeding 160/100 mmHg); 4. Those who have mental dysfunction before surgery and those who take psychotropic drugs before surgery; 5. Those who have a history of psychotropic drugs, opioids, and alcohol dependence; 6. Those who are allergic to the active ingredients of the drug used in this test or all excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of adverse events during the trial;Changes of vital signs during the test ; | — |
Countries
China
Contacts
Public ContactMengxing Jia
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed