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Clinical trial of hepatic arterial infusion chemotherapy combined with Sintilimab and Bevacizumab for unresectable liver cancer

Clinical trial of transcatheter arterial chemoembolization combined with immunotherapy and targeted therapy for unresectable liver cancer

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300073095
Enrollment
Unknown
Registered
2023-06-30
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

liver cancer

Interventions

Sponsors

the first affiliated hospital of Chongqing medical university
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 30 Years

Inclusion criteria

Inclusion criteria: ?Patients with liver cancer who undergo pathology or abdominal enhancement CT or MRI and meet the definition of primary liver cancer in 2022 Guidelines for the Treatment of Primary Liver Cancer. ?Measurable lesions meeting RECIST criteria. ? Unresectable defined as having four or more lesions with tumor occupying or more than 50% of the liver volume or with significant cirrhotic background, or tumor invasion of major vascular structures, and not amenable to one-stage surgical resection upon evaluation. ?Patients with previously untreated disease. ? liver function Child-Pugh classification grade A/B and Eastern U.S. Collaborative Oncology Group Physical Status Activity (ECOGPS) score <2. ? White blood cell count = 3.0*109/L and no renal, cardiac, cerebral or other significant organ insufficiency disease. ?Informed understanding of various treatment options and good compliance with outpatient follow-up, with complete follow-up data.

Exclusion criteria

Exclusion criteria: ? Patients with combined organic lesions of vital organs such as heart, brain and kidney or with other malignant tumors. ?Patients who have been treated for liver cancer in the past. ? Patients with decompensated liver function or liver function Child-Pugh classification grade C. ?patients with incomplete clinical data. ? Patients with poor medication compliance, pregnant or lactating women.

Design outcomes

Primary

MeasureTime frame
3-year survival rate;

Secondary

MeasureTime frame
Tumor progression;Liver and kidney function, blood routine, coagulation function, tumor markers, C-reactive protein;

Countries

People's Republic of China

Contacts

Public ContactDu Chengyou

the first affiliated hospital of Chongqing medical university

lanxiangkeyan@163.com+86 139 8370 1066

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026