Clinical study on the repair of cartilage defect by matrix induced autologous chondrocyte transplantation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300073094

Enrollment

Unknown

Registered

2023-06-30

Start date

2016-01-01

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee cartilage injury

Interventions

MACI treatment group:Matrix-induced autologous chondrocyte grafts

Conservative therapy group:Oral glucosamine sulfate + joint cavity injection

MACI+PRP group:MACI+PRP

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: Outerbridge grade III/IV focal knee cartilage defects with the following corresponding criteria: ? mature epiphysis, = 55 years old ? cartilage defect size of 2-9 cm2; with intact and healthy surrounding cartilage, the corresponding joint surface is intact (according to Outerbridge grading allows the maximum damage level II) ? meniscus without damage or can be repaired by ?No ligamentous defects or surgical reconstruction is possible ?Normal lower limb axis or surgical correction (inversion or valgus <5°) and normal patellofemoral trajectory ?Patients can cooperate with strict postoperative rehabilitation.

Exclusion criteria

Exclusion criteria: ? arthrofibrosis ? inflammatory arthropathy ? joint ankylosis ? contraindication to surgery ? BMI = 35.

Design outcomes

Primary

Measure	Time frame
Knee KOOS score;	—

Secondary

Measure	Time frame
Knee arthroscopy imaging level;	—

Countries

China

Contacts

Public ContactZhang Zhongwen

PLA General Hospital Third Medical Center (formerly General Hospital of the Chinese People's Armed Police Force)

wjzhangjjtt@163.com+86 151 6618 6285

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026