disorders of consciousness
Conditions
Interventions
Trial 1:transcranial direct current stimulation of 2 mA for 20 minutes in the left DLPFC area
Trial 2:transcranial direct current stimulation of 2 mA for 20 minutes in the right DLPFC area
Control:left/right DLPFC area sham stimulation
Sponsors
Huashan hospital, rehabilitation department, No12 Wulumuqi middle Rd, Jingan district, Shanghai
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients whose immediate family members volunteered to participate, signed the informed consent form on their behalf, and were able to complete the trial according to the protocol; (2) Diagnosis of MCS according to the CRS-R score; (3) Right-handedness; (4) having stable vital signs; (5) Age 18-80 years; (6) No use of neuromuscular blocking agents and sedatives within 24 hours prior to study participation; (7) No observed improvement in the state of consciousness within 1 week prior to the start of the study; (8) Duration of impaired consciousness was at least 28 days.
Exclusion criteria
Exclusion criteria: (1) Known pre-existing severe neurocognitive degenerative disease; (2) Metal implants in the head; (3) Craniectomy beneath the stimulated area (i.e., prefrontal cortex); (4) Previous history of epilepsy or current uncontrolled epilepsy; (5) Previous treatment with transcranial electrical stimulation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Coma Recovery Scale–Revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Outcome Scale;CPC cardiopulmonary coupled sleep monitoring;Electroencephalogram; | — |
Countries
China
Contacts
Public ContactWu Yi
Shanghai Huashan Hospital
Outcome results
None listed