nonerosive reflux disease
Conditions
Interventions
Normal esophageal motility group:None
Ineffective esophageal motility group:None
Healthy control group:None
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) 45 years = age = 60 years old; 2) approximately the same course of disease; 3) meeting the NERD diagnostic criteria: 1 having discomfort symptoms such as acid regurgitation and heartburn; 2) endoscopic negative; 3) pathological acid reflux; 4) no cardiac retardation or other primary or secondary esophageal motility disorders; 5) there is no serious defect of anti-reflux barrier, that is, gastroesophageal reflux disc grade (gastroesophagealflapvalve,GEFV) is I-III grade. 6) No diabetes, thyroid dysfunction or immune system related diseases or chronic diseases such as peptic ulcer, severe atrophic gastritis, liver cirrhosis, chronic pancreatitis; 7) No malignant tumors of digestive system or other systems; 8) patients who have not used antibiotics or probiotics in recent 3 months. 9) No proton pump inhibitors (protonpumpinhibitors,PPIs), H2 receptor antagonists, gastrointestinal prokinetic drugs; 10) patients who are not currently infected with helicobacterpylori,H.pylori; 11) women who are not currently pregnant or lactating; 12) no severe cardiopulmonary insufficiency; 13) no history of upper gastrointestinal surgery; 14) no history of mental illness, genetic or metabolic diseases. 15) voluntarily accept and abide by this research program, be able to tolerate relevant tests, and be able to complete the questionnaire independently under the guidance of the researcher. Inclusion criteria for healthy individuals: 1) 45 years old = age = 60 years old; 2) Good health condition; 3) Does not meet any diagnostic criteria for functional and organic diseases; 4) Patients who have not used antibiotics or probiotics in the past 3 months; 5) I haven't taken proton pump inhibitors (PPIs), H2 receptor antagonists, and Prokinetic agent in recent 8 weeks; 6) Patients who are currently not infected with Helicobacter pylori (H. pylori); 7) Female patients who are currently not pregnant or breastfeeding; 8) Voluntarily accept and comply with this research protocol, be able to tolerate relevant tests, and independently complete the survey questionnaire under the guidance of the researcher.
Exclusion criteria
Exclusion criteria: 1) Age > 60 years old or < 45 years old; 2) do not meet NERD diagnostic criteria; 3) have cardiac retardation or other primary or secondary esophageal motility disorders; 4) have severe anti-reflux barrier defect, i.e. GEFV grade IV; 5) have diabetes, thyroid dysfunction or immune system related diseases or chronic diseases such as peptic ulcer, severe atrophic gastritis, liver cirrhosis, chronic pancreatitis, etc. 6) patients with malignant tumors of the digestive system or other systems; 7) patients who have used antibiotics or probiotics in the past 3 months; 8) patients who have taken PPIs preparations, H2 receptor antagonists and gastrointestinal motility drugs in the past 8 weeks; 9) patients with H.pylori infection; 10) women who are currently pregnant or breastfeeding; 11) severe cardiopulmonary insufficiency; 12) history of upper gastrointestinal surgery. 13) History of mental illness, history of genetic or metabolic diseases; 14) unwilling to accept and comply with this study program, or unable to tolerate relevant tests, or unable to complete the questionnaire independently under the guidance of the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| flora;Esophageal motility; | — |
Secondary
| Measure | Time frame |
|---|---|
| BMI;Gender;Age; | — |
Countries
China
Contacts
Public ContactHe Suyu
Suining Central Hospital
Outcome results
None listed