Postoperative delirium
Conditions
Interventions
Case group (postoperative delirium developed within 3 days after surgery):None
Control group (no postoperative delirium developed within 3 days after surgery):None
Sponsors
Department of Anesthesiology of The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? Age =60 years old; ? OPCABG surgery was performed at selected time under general anesthesia; ? Diagnostic criteria for fragile brain function in non-acute stage: history of chronic stroke or TIA, more than half a year since the last attack, or clear cerebral infarction by CT or MRI (including lacunar infarction)
Exclusion criteria
Exclusion criteria: ? Emergency surgery; ? Preoperative history of acute stroke, preoperative delirium, schizophrenia, major depression, Parkinson's disease, epilepsy, or Alzheimer's disease; ? Inability to communicate before surgery due to severe mental, speech, hearing, or visual impairment; ? MMSE adjusted educational level (uneducated =19 points, primary school literacy =22 points, secondary school and above literacy =26 points); ? Patients with Child-Pugh grade C severe liver dysfunction, or patients with severe renal insufficiency need renal replacement therapy; ? Emergency CPB or IABP during operation; ? Ordered by attending physician to withdraw from the experiment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EEG burst-suppression duration;ROC curve;The incidence of postoperative delirium developed within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hypotension duration;Deep anesthesia (BIS < 40) duration;Hypothermia duration;Length of hospitalization;Length of ICU stay;Incidence of postoperative AKI;Postoperative WBC peak;Sensitivity; | — |
Countries
China
Contacts
Public ContactYang Jianjun
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed