Rosacea
Conditions
Interventions
Doxycycline combined with A probiotics group:Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics A 2 packs Qd for 16 weeks.
Doxycycline combined with B probiotics group:Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics B 2 packs Qd for 16 weeks.
Doxycycline combined with probiotics mimetic group:Oral Doxycycline 0.05 g Qd for 8 weeks and probiotics mimetic 2 packs Qd for 16 weeks.
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with rosacea (characterized by persistent erythema or pustular papule as the predominant phenotype) and those with voluntary informed consent.
Exclusion criteria
Exclusion criteria: Participants who met one of the following criteria were excluded from the trial: (1) age 65 years old; (2) pregnant and lactating women and those who have a recent pregnancy plan; (3) patients with diabetes mellitus, moderate or severe liver, kidney, lung or blood diseases; (4) patients with depression or mental disorders; (5) The facial manifestations of rosacea patients with the main clinical manifestations of hyperplasia and hypertrophy, or with other facial skin diseases (such as seborrheic dermatitis, eczema, etc.) or other systemic diseases (such as dermatomyositis, systemic lupus erythematosus) ; (6) participants in any clinical trial within one month; (7) use of probiotics (supplements or food enhancers) or oral antibiotics within 1 month before the start of the study; (8) patients who received any other form of rosacea treatment 1 month before the start of the study; (9) Allergic to probiotics or doxycycline; (10) other conditions that the researchers considered unacceptable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rosacea Clinical Symptom Severity Assessment (Physician Assessment);Rosacea Clinical Symptom Severity Assessment (Patient Assessment); | — |
Secondary
| Measure | Time frame |
|---|---|
| Skin Life Quality Index (DLQI) Questionnaire;Facial clinical photos and VISIA photos of patients with rosacea;Helicobacter pylori test, methane hydrogen test, intestinal microbiology test; | — |
Countries
China
Contacts
Public ContactBen Wang
Dermatology Hospital of Central South University Xiangya Hospital
Outcome results
None listed