Arthroplasty
Conditions
Interventions
Group A (Fibrinolytic ShutDown, FSD, no postoperative TXA):No postoperative TXA
Group B (Non-Fibrinolytic ShutDown, NFSD, no postoperative TXA):No postoperative TXA
Group C (Fibrinolytic ShutDown, FSD, receiving postoperative TXA):1.5g TXA i.v. q12h from postoperative days 1 to 3
Group D (Non-Fibrinolytic ShutDown, NFSD, receiving postoperative TXA):1.5g TXA i.v. q12h from postoperative days 1 to 3
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 18 years old; 2.Patients who need arthroplasty in the Department of orthopedics of our hospital
Exclusion criteria
Exclusion criteria: 1. Complicated with serious cardiovascular and cerebrovascular diseases (myocardial infarction, cerebral infarction, etc.); 2. Have obvious bleeding tendency (such as active gastrointestinal bleeding, cerebral hemorrhage, etc.); 3. Complicated with systemic or local venous thromboembolism (such as deep venous thrombosis, pulmonary embolism, etc.); 4. Previously identified coagulation dysfunction; 5. Complicated with severe neuromuscular system diseases; 6. Allergy to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transfusion rate;Transfusion volume;Thromboelastogram(TEG);Routine coagulation parameters(PT?PTR?INR?PTA?APTT?TT);Routine fibrinolysis parameters(FDP?D-D);Incidence of venous thromboembolism (DVT, PE);Wound complications (exudation, hematoma, infection); | — |
Countries
China
Contacts
Public ContactWei Huang
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed