Helicobacter pylori infection
Conditions
Interventions
experimental group:Esomeprazole + Amoxicillin
control group:Esomeprazole + Clarithromycin + Amoxicillin + Bismuth
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years old; 2. 13C Urea Breath Test (13C-UBT) or pathological determination of Hp infection; 3. Patients who have received treatment for the first time and meet the indications for eradication; The patient signs an informed consent form and is able to cooperate with the follow-up patient; 4. The penicillin skin test was negative.
Exclusion criteria
Exclusion criteria: 1. History of upper gastrointestinal surgery and important organ damage; previous eradication therapy for H.pylori; 2. Take drugs that affect the gastrointestinal microbiota before one month, during, and after the first collection of samples; 3. Pregnant or breastfeeding; 4. Allergic to the drugs used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal microbiota;Intestinal microbiota resistance genes; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hp eradication rate;Symptom relief rate;Incidence of Adverse drug reaction;compliance; | — |
Countries
China
Contacts
Public ContactYang Yunsheng
Chinese PLA General Hospital
Outcome results
None listed