Cerebrovascular diseases
Conditions
Interventions
RIC group:The patient received bilateral upper limb RIC (cuff pressure 180mmHg) twice a day for at least 7 consecutive days within 48 hours after operation. An entire intervention episode is composed
Conventional treatment group:Accept standardized diagnosis and treatment plans recommended by the guidelines
Sponsors
the First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Inclusion criteria
Inclusion criteria: ? Adults (age = 18 years old); ? Patients received teneplase thrombolytic (0.25mg/kg, maximum 25mg) followed by thrombectomy within 6 hours after onset or when the onset time was unknown but DWI and FLAIR imaging mismatching; ? Patients diagnosed with anterior circulation LVO-AIS by DSA (anterior circulation LVO was defined as occlusion of the internal carotid artery or the M1 and M2 segments of the middle cerebral artery); ? Premorbid mRS score =2; ? Patients or their legal representatives signed the informed consent.
Exclusion criteria
Exclusion criteria: ? Intracranial hemorrhage showed by cranial imaging examination within 24-36 hours after operation; ? The modified Thrombolysis in Cerebral Infarction grade after operation lower than 2b grade; ? Postoperative hemodynamic instability (blood pressure below 90/60mmHg or above 200/110mmHg after treatment); ? Pregnant or breastfeeding women; ? Any contraindications for RIC,such as severe soft tissue injury, fracture, thrombotic diseases, confirmed peripheral vascular lesions, active visceral bleeding, acute phase of fundus hemorrhage, cerebral aneurysms and cerebral arteriovenous malformations, or other situations deemed unsuitable for RIC treatment by researchers; ? Patients with a life expectancy of fewer than 90 days, or unwilling to be followed up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients with favorable functional outcomes (mRS=2) at 90 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| The neurological function (NIHSS and ADL scores) and cognitive function (MMSE and MoCA scores) of patients at 7 days;The neurological function (NIHSS and ADL scores) and cognitive function (MMSE and MoCA scores) of patients at 90 days;The neurological function (NIHSS and ADL scores) and cognitive function (MMSE and MoCA scores) of patients at 6 monthss;The proportion of patients with favorable functional outcomes (mRS=2) at 6 months;The proportion of patients with stroke recurrence within 6 months;The collateral circulation compensation of cerebral blood flow of patients at 6 months;Dynamic changes of HIF-1a, bFGF, vEGF, S100-ß and NSE in blood; | — |
Countries
China
Contacts
Public ContactYawen Cheng
the First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed