thyroid surgery
Conditions
Interventions
S group:0.25 mg/kg esketamine was administered intravenously at induction, followed by 0.125 mg/kg/h continuous intravenous infusion until 15 minutes before the end of the procedure
C group:0.25 mg/kg saline was administered intravenously at induction, followed by 0.125 mg/kg/h continuous intravenous infusion until 15 minutes before the end of the procedure
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18 to 65 years; (2) BMI 18 to 25 kg/m2; (3) ASA grade I or II; (4) Undergoing elective thyroid surgery; (5) Obtain the consent from the patient and family and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergic to anesthetic drugs; (2) Contraindicated for esketamine; (3) With severe organ dysfunction such as heart, lung, liver and kidney; (4) History of psychiatric system disorders or inability to cooperate with the test; (5) History of long-term sedative and analgesic drugs, history of drug use; (6) hyperthyroidism or hypothyroidism (7) Preoperative Pittsburgh Sleep Quality Index (PSQI) score >7; (8) Obstructive sleep apnea syndrome.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sleep quality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital anxiety and depression scale;QoR-15;Static and dynamic VAS scores;adverse reaction; | — |
Countries
China
Contacts
Public ContactWei Zhang
First Affiliated Hospital of Zhengzhou University
Outcome results
None listed