Application of follicle activation mechanism and developmental support in artificial ovarian reconstruction with autologous tissue

Application of follicle activation mechanism and developmental support in artificial ovarian reconstruction with autologous tissue - Artiticial ovarian reconstruction

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2300073013

Enrollment

Unknown

Registered

2023-06-29

Start date

2023-07-10

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility impairment

Interventions

Follicular isolation:Follicles were separated from cortex or medulla by mechanical enzyme digestion

Construction of artificial ovarian matrix:Ovarian tissue mass decellularization

Artificial ovary reconstruction in vitro:The isolated follicles and acellular matrix were reconstructed in vitro

Eligibility

Sex/Gender

Female

Age

No minimum to 45 Years

Inclusion criteria

Inclusion criteria: 1. Cancer patients who are willing to undergo fertility preservation; 2. Gynecological operation requires ovariectomy;

Exclusion criteria

Exclusion criteria: 1. Women over 45 years of age or post-menopausal

Design outcomes

Primary

Measure	Time frame
Follicle survival rate;Residue rate of Cancer cell ;	—

Secondary

Measure	Time frame
Follicular development rate;Cytokine;	—

Countries

China

Contacts

Public ContactJunping Cheng

Center of Reproductive and Genetic, People's Hospital of Guangxi Zhuang Autonomous Region

chengjunpingyy@163.com+86 137 6830 8416

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026