neoplastic hematologic disorder
Conditions
Interventions
For the first test, peripheral blood was sampled before transplantation, Immune group library TCR sequencing:N/A
The second test, the first peripheral blood after transplantation, Immune group library TCR sequencing:N/A
The third test, the second peripheral blood collection after transplantation, Immune group library TCR sequencing:N/A
Sponsors
Department of Hematology, Fifth Medical Center, Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Receptor inclusion criteria: 1) Age =14 years old, gender unlimited; 2) Recipients that meet the requirements for hematopoietic stem cell transplantation; 3) Hematopoietic stem cell transplant recipients must have received hematopoietic stem cell transplantation; 4) ECOG score less than or equal to 1; 5) Major organ function is normal, meeting the following definitions: Blood routine examination: neutrophil count = 1.0 x 10^9/L, small blood Plate = 75 x 10^9/L, hemoglobin = 80 g/dL; Liver and kidney function: AST and ALT = 3.0 upper limit of normal value; Bilirubin =2.0 mg/dL; Creatinine clearance = 60 mL/min; Liver and kidney function impairment caused by tumor compression was not restricted. 6) Consent to use effective contraceptive methods; 7) Understand and voluntarily sign written informed consent. Donor admission criteria: 1) Age =14 years old, gender unlimited; 2) Donors that meet the requirements for hematopoietic stem cell transplantation; 3) Adequate venous access is available for peripheral blood leucocyte separation, or consent to the use of temporary central venous catheter for leucocyte separation; 4) Voluntarily sign written informed consent.
Exclusion criteria
Exclusion criteria: Receptor exclusion criteria: 1) have other tumors (excluding non-melanoma skin cancer and in situ cervical cancer, bladder cancer, and breast cancer with disease-free survival of more than 5 years); 2) People with severe mental disorders; 3) A history or disease of the central nervous system, such as seizure disorder, cerebral ischemia/bleeding, dementia, cerebellar disease, or any autoimmune disease involving the CNS; 4) There is an infection that needs to be treated, and the infection should be controlled before re-admission; 5) Any of the following virological test results are positive: human immunodeficiency virus, hepatitis C virus, hepatitis B virus surface antigen, hepatitis B surface core antibody; 6) Patients with severe allergic history or allergic constitution; 7) There are other active malignant tumors that may interfere with the study and require treatment; 8) According to the investigators, the patient had other conditions that were not suitable for enrollment. Donor exclusion criteria: 1) A history of mental disorders that may affect compliance with this Agreement or inability to sign informed consent; 2) A history of uncontrolled high blood pressure, stroke, or serious heart disease (other than angina). Asymptomatic donors with a history of coronary artery bypass grafting or angioplasty will be evaluated in cardiology; 3) There is anemia or small blood plate symptoms. Donors with Hb level < 110g/L due to iron deficiency are eligible for donation after starting iron supplementation. 4) Any of the following virological surveillance results are positive: HIV; HCV; HbsAg; HBcAb; 5) Pregnant donor; 6) any other circumstances deemed unsuitable for inclusion by the researcher;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VDJ gene; | — |
Secondary
| Measure | Time frame |
|---|---|
| TCR/BCR diversity; | — |
Countries
CHINA
Contacts
Public Contactjian bo
Chinese PLA General Hospita
Outcome results
None listed