Skip to content

The anti-inflammatory and analgesic mechanism of one finger pushing manipulation for knee osteoarthritis based on Piezo1-ERK1/2

The anti-inflammatory and analgesic mechanism of one finger pushing manipulation for knee osteoarthritis based on Piezo1-ERK1/2

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072997
Enrollment
Unknown
Registered
2023-06-29
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

Health education Group:Health education is the first step in the treatment ladder of the KOA medical guidelines. The health education is implemented by having KOA patients attend 45-minute health educ
One finger pushing manipulation treatment group:On the basis of health education, one finger pushing manipulation was added. Health education program refer to the Health Education Group. One finger pu

Sponsors

Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
38 Years to 70 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria of Chinese and Western medicine for knee osteoarthritis; (2) Age =38 years old and =70 years old, gender unlimited; (3) Volunteer to participate in the study and sign the informed consent; (4)KL is graded as Class I or II.

Exclusion criteria

Exclusion criteria: (1) Knee trauma and surgical history; (2) Patients with tumors, tuberculosis, osteomyelitis and other diseases in the knee; (3) Psoriasis, syphilitic neuropathy, brown yellow disease, metabolic bone disease, acute trauma, etc.; (4) Severe liver and kidney insufficiency, severe cardiovascular disease, diabetes and mental disease; (5) Patients with metal implants or claustrophobia and other MRI contraindications.

Design outcomes

Primary

MeasureTime frame
Western Ontario and McMaster Universities Osteoarthritis Index;

Secondary

MeasureTime frame
Knee MRI;IL-1ß;IL-6;TNF-a;

Countries

China

Contacts

Public ContactHua Xing

Yueyang Hospital of Integrated Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine

yyyyxinghua@shutcm.edu.cn+86 21 6516 1782

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026