Type 2 diabetes combined with overweight/obesity
Conditions
Interventions
Experimental group:The original treatment regimen was maintained while semaglutide was added
Control group:The original hypoglycemic scheme was adjusted without the use of semaglutide
Sponsors
the Sixth Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1: Patients with type 2 diabetes who meet the diagnostic criteria of Chinese Type 2 Diabetes Prevention Guidelines (2020) 2: Age =18 years and =65 years 3: Body mass index (BMI) = 24 kg/m2 4: Glycosylated hemoglobin (HbA1c) = 7.5% and = 9% 5: The dosage form and dose of the original hypoglycemic regimen remained stable for at least 8 weeks, and no significant changes were made to the original lifestyle (the original hypoglycemic regimen allowed the use of single or combined hypoglycemic drugs recommended by the guidelines, including sulfonylureas, metformin, glenides, TZD, a-glycosidase inhibitors, and SGLT2i) 6: Sign the informed consent and comply with the study protocol.
Exclusion criteria
Exclusion criteria: 1: Patients with other types of diabetes such as type 1 diabetes, special type diabetes, etc. 2: Patients with severe acute and chronic diabetes complications 3: Patients with mental illness who cannot cooperate with the experiment 4: Pregnant and lactating women 5: Secondary obesity, such as hypothyroidism and Cushing's syndrome 6: Long-term use of drugs that affect weight (such as orlistat, glucocorticoids, etc.) 7: Received GLP-1RA, DPP4i and insulin therapy within the first 3 months 8: Previous personal or family history of medullary thyroid carcinoma, or type 2 multiple endocrine tumor syndrome 9: Severe liver function injury, severe renal insufficiency, and severe heart failure (NYHA III-IV) 10: Allergic patients to Semaglutide and its excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle mass in both groups before and after treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure;Fasting blood glucose;HbA1c;blood lipid;albumin;liver and kidney function;height;weight; | — |
Countries
China
Contacts
Public ContactHuang Qiya
the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital, Qingyuan, CHINA
Outcome results
None listed