asthenopia
Conditions
Interventions
Healthy control group :Asthenopia scale score,binocular visual function examination and functional magnetic resonance imaging scan were performed.
Patients with accommodative asthenopia group:Asthenopia scale score,binocular visual function examination and functional magnetic resonance imaging scan were performed.
Sponsors
the Second Affiliated Hospital of Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers:(1) Age 18-45 years old;(2) Right-handed;(3) Right dominant eye (card hole examination); (4) Eye strain Scale score<16 (Wenzhou Medical University Eye strain Scale Professional Edition);(5) No somatization or mental symptoms;(6) Understand the experimental process of this study and sign an informed consent form. Patient:(1) age 18-45 years old, regardless of gender, right-handed, with the right eye as the main visual eye,ASS score=16, and astigmatism<-2.00 D, and pseudomyopia was allowed; (2) symptoms consistent with the diagnosis of asthenopia:1)nondurable vision, temporary distant blurred vision; 2)dry and astringent eyes, foreign body sensation, burning sensation, itching, photophobia, swelling pain and tears; and 3)dizziness, headache, anxiety and insomnia; asthenopia can be diagnosed if it meets 3/5 of symptoms 1) and 2); and (3) visual function parameter examination showing excessive accommodation --- monocular accommodation sensitivity < 6 cycles per minute (cpm) (+2.00 D lens difficulty) or combined with accommodation response <+0.25 D, negative relative accommodation <+1.50 D, binocular accommodation sensitivity (+2.00 D lens difficulty) <3 cpm; (4) not having taken drugs such as antihistamines, anticholinergics, thyroid hormones, antidepressants, antithyroid drugs and Ginkgo biloba extract. (5) The time of near-range eye use in working days was more than 5 hours per day (Data were collected through ASS by patients' autonomous near-range eye use time assessment).
Exclusion criteria
Exclusion criteria: (1) were pregnant or lactating women; (2) had major organ dysfunction; (3) had horizontal oblique, vertical oblique or obvious oblique; (4) suffered from acute conjunctivitis, corneal diseases, other infectious eye diseases, glaucoma, mild to moderate dry eyes with corneal punctate staining and severe dry eyes; and (5) had a history of eye surgery within 1 month; and patients with visual fatigue had already been treated with esculin and digitalisglycoside eye drops or other eye drops in the previous 1-3 weeks. (6) sleep time was less than 5 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amplitude of low frequency fluctuation;Coherent regional homogeneity;Independent component analysis;Static functional network connectivity;Dynamic functional network connectivity;Analysis of task-state indicators;asthenopia scale score;ocular accommodative parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation analysis among ALFF, fALFF, CoheReHo values and ASS score; | — |
Countries
China
Contacts
Public Contactxiaoli lv
the Second Affiliated Hospital of Zhejiang Chinese Medical University
Outcome results
None listed