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The clinical application value of Frank's sign and Neurofilament Light Chain levels in predicting perioperative neurocognitive dysfunction

The clinical application value of Frank's sign and Neurofilament Light Chain levels in predicting perioperative neurocognitive dysfunction

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300072971
Enrollment
Unknown
Registered
2023-06-29
Start date
2023-06-29
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diagonal Earlobe Crease(Frank’s Sign)

Interventions

Classification according to the death of Frank's sign(Group 0/Group I/Group IIa/Group IIb /Group III):NO

Sponsors

Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 90 Years

Inclusion criteria

Inclusion criteria: (1) Patients undergoing non-cardiac and non-neurosurgical procedures under general anesthesia; (2) American Society of Anesthesiologists (ASA) Grade ?-?; (3) Age 60-90 years old

Exclusion criteria

Exclusion criteria: (1) Preoperative history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; (2)MMSE score,illiterate=19;1-6 years of education years=22;greater than 7 years=26(3) severe dysfunction of heart, liver, lung,or kidney function; (4) A history of alcoholism or the current long-term use of sedatives or analgesics, antidepressants; (5) Inability to communicate before surgery (coma, severe dementia, speech disorder); (6) Ear surgery history; (7) Other conditions considered unsuitable for inclusion by the researchers.

Design outcomes

Primary

MeasureTime frame
postoperative delirium;postoperative cognitive function;Concentration of neurofilaments light chain;Grading of Frank's sign ;

Secondary

MeasureTime frame
Biological marker;Hemodynamics;drug dosage;postoperative complications;

Countries

China

Contacts

Public ContactSheng Wang

Department of Anesthesiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China

iamsheng2020@ustc.edu.cn+86 191 5600 7726

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026