Diagonal Earlobe Crease(Frank’s Sign)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Patients undergoing non-cardiac and non-neurosurgical procedures under general anesthesia; (2) American Society of Anesthesiologists (ASA) Grade ?-?; (3) Age 60-90 years old
Exclusion criteria
Exclusion criteria: (1) Preoperative history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; (2)MMSE score,illiterate=19;1-6 years of education years=22;greater than 7 years=26(3) severe dysfunction of heart, liver, lung,or kidney function; (4) A history of alcoholism or the current long-term use of sedatives or analgesics, antidepressants; (5) Inability to communicate before surgery (coma, severe dementia, speech disorder); (6) Ear surgery history; (7) Other conditions considered unsuitable for inclusion by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium;postoperative cognitive function;Concentration of neurofilaments light chain;Grading of Frank's sign ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Biological marker;Hemodynamics;drug dosage;postoperative complications; | — |
Countries
China
Contacts
Department of Anesthesiology, Anhui Provincial Hospital, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China