Orthopedic surgery postoperative delirium
Conditions
Interventions
Group 1:Give dexmedetomidine a fixed load of 0.5 µg/kg, intraoperative infusion rate 0.5 µg/kg·h
Group 2:Intraoperative infusion of physiological saline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 60-80 ASA < Grade IV Planned to undergo unilateral total hip/knee replacement under general anesthesia
Exclusion criteria
Exclusion criteria: Communication barriers Patients with preoperative cognitive impairment measured by the Concise Mental Rating Scale Severe arrhythmia, heart failure, acute coronary syndrome, severe liver and renal dysfunction History of gastrointestinal surgery, inflammatory bowel disease, irritable bowel syndrome, gastroenteritis, constipation, gastrointestinal ulcers, gastrointestinal bleeding, diarrhea, use of salicylic acid preparations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sample species composition and community structure;Duration and severity of delirium;Postoperative MMSE score, anxiety score, and pain score (days 1-5); | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed