Effect of dexmedetomidine combined with modified Trendelenburg position on intraocular pressure during robot-assisted laparoscopic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300072961

Enrollment

Unknown

Registered

2023-06-28

Start date

2023-07-01

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraocular pressure increased during operation

Interventions

Dexmedetomidine/Traditional position group:Dexmedetomidine was continued immediately after induction of anesthesia at a dose of 0.4µg/kg/h until the end of surgery. The patient lies supine on the oper

Dexmedetomidine/Modified position group:Dexmedetomidine was continued immediately after induction of anesthesia at a dose of 0.4µg/kg/h until the end of surgery. The patient lies supine on the operat

Saline/Traditional position group:Continuous saline infusion at the same rate. The patient lies supine on the operating table with the head tilted at the foot about 25-40 degree.

Saline/Modified position group:The saline/modified position group received continuous saline infusion at the same rate. The patient lies supine on the operating table and is adjusted again to raise th

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Patients undergoing robot-assisted laparoscopic radical prostatectomy under general anesthesia, colorectal cancer surgery, and gynecological surgery; 2.Age =18 years old; 3. Operation duration =3h 4. ASA rating :I-III

Exclusion criteria

Exclusion criteria: 1. Patients with eye diseases (glaucoma, diabetic retinopathy, cataracts and retinal detachment); 2. Baseline IOP > 30mmHg; 3. Patients with a history of ophthalmic surgery; 4. Patients with a history of dexmedetomidine allergy; 5. Hypotension, uncontrolled hypertension, bradycardia <60 times /min, abnormal ventricular conduction, congestive heart failure; 6.Liver failure, kidney failure; 7. Patients with neurological or mental illness.

Design outcomes

Primary

Measure	Time frame
T3 intraocular pressure;	—

Secondary

Measure	Time frame
Mean arterial pressure;End-expiratory carbon dioxide;Peak Inspiratory Pressure;Ocular complications within 72 hours after surgery;Intraocular pressure compared in each group;	—

Countries

China

Contacts

Public ContactJindong Liu

Affiliated Hospital of Xuzhou Medical University

liujindong1818@163.com+86 139 5135 5136

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Mar 29, 2026