nicotine addiction
Conditions
Interventions
No smoking + nicotine cue extinction group:(No smoking after 18:00 the night before) Combined with cue exposure therapy, nicotine addicts were repeatedly presented with nicotine cue picture stimuli fo
Non-smoking + neutral cue extinction group:(No smoking after 18:00 the night before) combined with cue exposure therapy, by repeatedly presenting neutral cue picture stimuli to nicotine addicts, and p
No smoking + fasting + nicotine cue extinction group:(No smoking + fasting after 18:00 the night before) Combined with cue exposure therapy, nicotine addicts are repeatedly presented with nicotine cue
No smoking + fasting + neutral cue extinction group:(No smoking + fasting after 18:00 the night before) Combined with cue exposure therapy, nicotine addicts were repeatedly presented with neutral cue
No smoking + nicotine cue extinction group:(No smoking + fasting after 18:00 the night before), after breakfast at 8:00 in the morning, combined with cue exposure therapy, by repeatedly presenting neu
Healthy control group:N/A
Sponsors
Shenzhen Kangning Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for smokers: a. Age 18-60 years old, gender is not limited; b. Nicotine addicts, meeting the DSM-V diagnostic criteria for substance dependence, that is, smoking = 10 cigarettes per day and smoking age = 2 years; c . Be able to communicate normally with the researcher and cooperate with the researcher; d. Informed consent, voluntary participation. Inclusion criteria for healthy subjects: a. Voluntarily participate in this clinical study and sign the informed consent; b. Age 18-60 years old, gender is not limited; c. The total lifetime smoking amount before the participation in the subject is <10 and within the past year Non-smoking; d. Be able to communicate normally with the researcher and cooperate with the researcher to complete the research.
Exclusion criteria
Exclusion criteria: Exclusion criteria: 1) Those with psychotic symptoms or a family history of mental disorders; 2) Those with a history of dependence or behavior (gambling, online games) addiction other than alcohol, drugs, etc.; 3) Those who are receiving any drug treatment or Those who have taken benzodiazepines or received antipsychotic drugs within 2 weeks; 4) Those with epilepsy, craniocerebral injury history, coma history, brain organic or serious physical disease; 5) Due to obesity and smoking There is an interaction 29, and obese people with a body mass index (BMI) > 30 are excluded; 6) Those with intracranial metal implants or artificial dental implants, and those who cannot tolerate magnetic resonance examinations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| smoking craving;exhaled CO concentration;Changes in plasma orexin concentration levels;MRI imaging changes; | — |
Countries
China
Contacts
Public ContactHuang Gengdi
Shenzhen Kangning Hospital
Outcome results
None listed