Pain
Conditions
Interventions
ASI group:PCIA pump: sufentanil 2ug/kg + esketamine 0.5mg/kg
ASII group:PCIA pump: sufentanil 2ug/kg + esketamine 1mg/kg
S group:PCIA pump: sufentanil 3ug/kg
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age :30~75 years old; (2)BMI(kg/m2):18~30; (3) American Society of Anesthesiologists (ASA) anesthesia grades:???; (4) Patients diagnosed with hepatocellular carcinoma by abdominal B ultrasound, alpha-fetoprotein examination, liver computed tomography or magnetic resonance imaging; (5) Patients who intend to complete TACE under anesthesia sedation and analgesia; (6) Voluntary participation in the trial; (7) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Preoperative patients with other tumors; (2) Those with uncontrolled hypertension or cardiovascular disease; (3) Fever caused by infection; (4) Mentally ill or uncooperative; (5) Those who are allergic to esketamine; (6) Those who are hearing impaired and unable to cooperate with the completion of the questionnaire; (7) Patients who use painkillers before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of moderate and severe pain in patients within 72 hours after TACE surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS scores at the end of surgery, 6h, 24h, 48h, and 72h after surgery;Ramsay sedation scores at the end of surgery, 6h, 24h, 48h, and 72h after surgery;Postoperative recovery quality score (QoR-15) at 24h, 48, and 72h postoperative;Hospital Anxiety and Depression Scale (HADS) scores for 72 hours before and after surgery; | — |
Countries
China
Contacts
Public ContactOu Wei
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed