Heart Disease
Conditions
Interventions
Qishen granule optimization group:On the basis of standardized western medicine treatment, Qishen granule optimized prescription was given for 12 weeks.
Qishen granule original prescription group:On the basis of standardized western medicine treatment, Qishen granule optimized prescription and Qishen granule original prescription were given.
placebo group:On the basis of standardized Western medicine treatment, placebo granules are given.
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of chronic heart failure (see Appendix 1 for details); 2. Meet the diagnostic criteria of dilated heart disease (see Appendix 2 for details); 3. Meet the diagnostic criteria of heart failure syndrome of heart failure (note: the diagnostic criteria of heart failure syndrome are drawn up after pre-epidemiological investigation); 4. LVEF = 600 PG mL; 5. NYHAII-III grade; 6. Aged 18-80 years; 7. Volunteer to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Acute stage of myocardial infarction; 2. Severe hepatic insufficiency (ALT > 100 U/L or AST > 100 U/L), severe renal insufficiency (glomerular filtration rate 5.5 mmol/L); 3. Blood diseases and malignant tumors; 4. Pregnant or lactating women; 5. Psychiatric patients; 6. Uncontrollable hypertension or diabetes; 7. People who are allergic to experimental drug ingredients; 8. Those who take experimental drugs, other traditional Chinese medicine or proprietary Chinese medicine within one month; 9. Those who are known to have adverse reactions to research drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction, LVEF;NT-proBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular end-diastolic diameter, LVEDD;Left ventricular end-systolic diameter, LVESD;interventricular septal thickness (IVST);LVPW, left ventricular posterior wall thickness;Left ventricular fractional shortening (FS);E/E’;E/A;TCM syndrome integral;ST2;NYHA cardiac function classification;Minnesota Heart failure quality of Life scale;Grading and quantification table of heart failure symptoms;6MWT, 6-minute walking test; | — |
Countries
China
Contacts
Public ContactLi Rong
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed