Comparison of effects of remazolam and propofol general anesthesia on inflammatory response indexes after laparoscopic hepatectomy

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300072885

Enrollment

Unknown

Registered

2023-06-27

Start date

2023-07-01

Completion date

Unknown

Last updated

2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver disease

Interventions

LR group:Anesthesia induction: remazolam 6mg/kg/h=3min Anesthesia maintenance: low-dose remazolam 0.3-0.5 mg/kg/h

HR group:Anesthesia induction: remazolam 6mg/kg/h=3min Anesthesia maintenance: high-dose remazolam > 0.5 mg/kg/h

P group:Anesthesia induction: propofol 2mg/kg/h=3min Anesthesia maintenance: propofol 2-4mg/kg/h

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Patients undergoing hepatectomy under elective intravenous combined with general anesthesia; (2) Age: 18-65 years old; (3)BMI:18-24kg/m2; (4) Sign the informed consent form.

Exclusion criteria

Exclusion criteria: (1) Patients with severe liver and kidney function decompensation; (2) Patients with psychosis and severe neurosis who cannot cooperate (3) Patients with neuromuscular system diseases; (4) Patients with severe cardiovascular and cerebrovascular diseases; (5) Patients with metastasis or severe cancer pain combined with other malignant tumors (6) Pregnant or lactating women (7) Patients who are allergic to any of the drugs in this trial

Design outcomes

Primary

Measure	Time frame
CRP;PCT;Esr;IL-6;INF-?;TNF-a;	—

Countries

China

Contacts

Public ContactZi Ying Lu

Guangzhou Panyu Central Hospital

954450740@qq.com+86 188 1945 7507

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026