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Predictive, diagnostic and prognostic evaluation and pathogenesis of placental dysfunction in hypertensive disorders in pregnancy by combining biological markers and ultrasound imaging at different stages of pregnancy

Predictive, diagnostic and prognostic evaluation and pathogenesis of placental dysfunction in hypertensive disorders in pregnancy by combining biological markers and ultrasound imaging at different stages of pregnancy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300072879
Enrollment
Unknown
Registered
2023-06-27
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypertensive disorders in pregnancy

Interventions

Grouping is based on the first occurrence of elevated blood pressure (systolic blood pressure = 140 mmHg or diastolic blood pressure = 90 mmHg) after 20 weeks of pregnancy :none

Sponsors

Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Women with singleton pregnancies who are naturally conceived, intrauterine pregnancy diagnosed within 10 weeks of pregnancy, registered and delivered in our hospital 2. Age 20-45 years old. 3. No other pregnancy complications such as heart disease, diabetes, thyroid dysfunction, intrahepatic cholestasis, and other metabolic diseases. 3.NO combined medical disease . 4. Regular prenatal check-ups, complete clinical and follow-up data, pregnant women and their family members have good communication and understanding skills, and can actively cooperate with clinical follow-up work.

Exclusion criteria

Exclusion criteria: 1.Multiple pregnancy. 2.Combined with other diseases. 3.Unwilling or unable to sign informed consent. 4.Fetal chromosomal abnormalities or intrauterine death.

Design outcomes

Primary

MeasureTime frame
Thromboelastogram;Bilateral uterine artery early diastolic notch and S/D value;Serum and urine metabolitive levels;Placental growth factor;Disseminated intravascular coagulation;Soluble fms-like tyrosine kinase 1,sFlt-1;Vascular endonthelial growth factor;Progesteron;Human chorionic gonadotropin;Umbilical artery S / D;Placental pathology;Umbilical cord blood metabolites;

Countries

China

Contacts

Public ContactYang Zhongmei

Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China

yangzm212@163.com+86 159 2810 6816

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026