stress ulcer
Conditions
Interventions
experimental group:Esomeprazole 40 mg in saline 100 ml q12h ivgtt
Sponsors
Zhongda Hospital Southeast University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-80 years, regardless of gender; 2. Patients with indications for stress ulcer prevention; 3. Patients who were treated with esomeprazole; 4. ICU patients with gastric tube indwelling, fasting > 12 hours, and expected to remain fasted > 72 hours; 5. Patients or family members voluntarily participated in this clinical trial and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with known or suspected allergy or contraindication to the study drug; 2. Patients with expected survival 4; 6. Patients who may require surgical treatment during the study drug treatment ; 7. Patients with hemodynamic instability (difficult to maintain MAP >= 65 mmHg despite norepinephrine >= 1 ug/kg/min or more); 8. Patients who have used esomeprazole within 12h prior to enrollment and used drugs affecting gastric juice PH within 24 hours prior to enrollment; 9. Use of some drugs affecting the blood concentration of the study drug within the last 1 week, such as clarithromycin, erythromycin, fluconazole, voriconazole, etc.; 10. Application of high-dose steroids or non-steroidal anti-inflammatory drugs within the last 2 weeks; 11. Patients who participated in any clinical trial as a subject within 1 month prior to the screening period; 12. Pregnant or lactating women; 13. Other conditions that are judged by the investigator as unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetic profile of esomeprazole in critically ill patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| pH value of gastric juice;CYP2C19 enzyme activity; | — |
Countries
China
Contacts
Public ContactXian Zha
Zhongda Hospital Southeast University
Outcome results
None listed