Hidradenitis suppurativa
Conditions
Interventions
Experimental Side:Micro-unroofing drainage+Intralesional photodynamic therapy
Control side:Micro-unroofing drainage
Sponsors
Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ?Age between 18 and 60 years old (including upper and lower limits), regardless of gender; ?Diagnosed as hidradenitis suppurativa (Hurley II or III) ; ?Bilateral symmetrical affected areas in axilla, under breast, back, groin or buttocks, and bilateral recurrent abscesses or non-extensively penetrating sinus, without extensively penetrating sinus; ?Voluntarily sign the informed consent form and voluntarily cooperate with the requirements of the protocol to complete all the follow-up of the clinical study on time; ?Female subjects agreed to use contraception from the time of signing the informed consent form to the end of the last follow-up.
Exclusion criteria
Exclusion criteria: ?Those who did not fill in the informed consent form and could not accurately describe the condition; ?History of photosensitive diseases, such as solar urticaria, polymorphic solar eruption, lupus erythematosus, erythropoietic protoporphyria, etc.; ?Patients with clinically important cardiovascular, nervous, metabolic, liver and other important organ system diseases, tumors or mental disorders; ?Patients with diseases that seriously affect wound healing, severe coagulopathy or a history of keloids; ?Those who are pregnant or lactating, or plan to be pregnant during the trial; ?Subjects who were deemed by the investigator to be unfit for trial participation for other reasons. (The following applies to subjects receiving microecological sampling) ?Systemic use of retinoids, immunosuppressants or biologics within 3 months before sampling; ?Systemic antibiotic therapy within 1 month prior to sampling; ?Topical antibiotics have been used within 2 weeks before sampling, antibacterial emollients/body wash have been used within 1 week before sampling, or bathing or deodorant has been used within 24 hours before sampling.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HiSCR rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| HiSCR rate;IHS4;mSS;VAS score;Sum of the maximum long diameters of sinus tracts; | — |
Countries
China
Contacts
Public ContactBaoxi Wang
Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College
Outcome results
None listed