Diseases of the biliary and pancreatic ducts
Conditions
Interventions
E:Esketamine is maintained at 0.15mg/kg/h after 0.15mg/kg/h intravenously
R:Pump refentanil 0.025ug/kg/min to maintain
D:The injection load of dexmedetomidine pump is 0.5ug/kg and maintained at 0.5ug/kg/h after 10min
Sponsors
Shanghai Putuo District Central Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patient's age= 60 years old; 2. American Association of Anesthesiologists Anesthesia Grade: Grade I-III; 3. Those who have indications for surgery; 4. Those with normal liver and kidney function; 5. Those with normal coagulation function; 6.Patients and families voluntarily sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Those with infectious diseases and blood system diseases; 2. Those with elevated blood lactate or metabolic disorders; 3. Patients with end-stage chronic diseases, active bleeding, severe pulmonary hypertension, heart failure and acute myocardial infarction; 4. Those with a history of contraindications to surgery; 5. Those with a history of contraindications to anesthesia; 6. Accompanied by serious infection and abnormal function of important organs (heart, brain, lung, etc.); 7. Those who cannot cooperate with researchers due to mental disorders or mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamics;Respiratory mechanics;Regulation of visceral autonomic function;Cognitive function in patients after anesthesia;Perioperative blood tests; | — |
Secondary
| Measure | Time frame |
|---|---|
| CAM scores were performed 24 h postoperatively, 48 h postoperatively, and 72 h postoperatively;Pittsburgh sleep quality index (PSQI) 1d before and 72h after surgery;Evaluation of surgeon and patient satisfaction;Surgery time, end of operation to BIS value> 85 awakening time;Aldrete scored > 9 for resuscitation room time;Total propofol;Number of nausea and vomiting in the patient; | — |
Countries
China
Contacts
Public ContactJuan lV
Shanghai Putuo District Central Hospital
Outcome results
None listed