Mild cognitive impairment
Conditions
Interventions
Intervention group:Take yeast beta-glucan capsules 250mg/ capsule daily, 2 capsules in the morning and night
Placebo group:Take starch capsules 250mg/ capsule every day, 2 capsules in the morning and evening
Sponsors
Shiyan City, Hubei Province, Hubei Medical College affiliated Sinopharm Dongfeng General Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) 50-80 years old; (2) Permanent residents of Shiyan City; (3) Meet the diagnostic criteria of MCI; (4) Willing to cooperate in completing questionnaire survey and clinical examination, and sign informed consent; (5) Did not participate in other clinical trials in the past 3 months. The diagnostic criteria for MCI are as follows: (1) The subjective feeling of memory loss > 3 months; (2) Objective examination of mild cognitive dysfunction, 18 points = MoCA score = 25 points (education years less than 6 years, the total score added 1 point to evaluate); (3) No depression, GDS-30 scale =10 points; (4) The basic activities of daily living were normal, but the instrumental activities of daily living (ADL) score scale =18 points; (5) had not reached the diagnostic criteria for dementia, and the CDR scale score was equal to 0.5 points.
Exclusion criteria
Exclusion criteria: (1) alcohol or drug abuse; (2) Patients with neurological diseases that may cause cognitive dysfunction, including cerebrovascular diseases, stroke, brain tumors, Parkinson's disease, active epilepsy, etc.; (3) A history of severe head trauma; (4) severe sensory and perceptual impairment, unable to complete the cognitive function measurement; (5) Have a history of mental illness such as depression, mania, anxiety, or take psychiatric drugs; (6) serious heart, lung, liver, kidney dysfunction, malignant tumors, etc.; (7) Suffering from autoimmune diseases; (8) Trauma, spinal injury or any disease that may affect the motor function of the limb; (9) Recent infectious diseases, acute gastrointestinal diseases; (10) Take antibiotics, probiotics, prebiotics or Biostime products within the last 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MoCA score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function tests in different areas;Detection of lymphocyte subsets(YNMT)· ;Plasma inflammatory factor; | — |
Countries
China
Contacts
Public ContactXiulou Li
Sinopod Dongfeng General Hospital, 16 Daling Road, Zhangwan District, Shiyan City, Hubei Province
Outcome results
None listed