Alllergic rhinitis
Conditions
Interventions
Experimental group:Allergen immunotherapy
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: ? In line with the "Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2015)" guidelines for the diagnosis of allergic rhinitis. ? Age: 5-12 years old (gender is not limited) ? Serum house dust mite/dust mite specific IgE = 0.35 or mite allergen skin test =++. ? In line with ARIA guidelines for allergen-specific immunotherapy indications and no contraindications. ? Agree to carry out nasal allergen challenge test and nasal secretion collection. ? The parents/legal guardians of the children must sign the informed consent form for the children to participate in this study.
Exclusion criteria
Exclusion criteria: A "yes" result for any of the following criteria will not be eligible for selection. ? Received allergen-specific immunotherapy in the past. ? Received treatment with systemic glucocorticoids, omalizumab, dupilimumab and other biological agents in the past 6 months. ? Combined with chronic sinusitis/nasal polyps (examination based on clinical history, electronic nasal endoscopy and/or sinus CT examination if necessary). ? Dust mites are not major allergens. ? Those who are currently at the onset of diseases such as upper respiratory tract infection, acute sinusitis, acute otitis media or other related infectious diseases or are receiving treatment. ? Diagnosis of heart, lung, liver, kidney, blood and other basic diseases. ? Those who are receiving beta-blocker therapy. ? Those who have allergies, hypersensitivity reactions or intolerance to emergency medicines. ? Mentally disabled, unable to understand the nature, significance and expected consequences of the research, and/or uncooperative attitude.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;TNSS;Proteomics of nasal secretions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum proteomics;Dust mite allergen components; | — |
Countries
China
Contacts
Public ContactBaoqing Sun
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed