intrauterine adhesion
Conditions
Interventions
Hyperbaric oxygen group:Receiving daily hyperbaric oxygen therapy (HBOT) during endometrial preparation
Control group:Receiving conventional method preparing endometrium
Sponsors
Xiangya Hospital, Central South University
Eligibility
Sex/Gender
Female
Age
20 Years to 51 Years
Inclusion criteria
Inclusion criteria: (i) patients undergoing frozen embryo transfer procedures; (ii) diagnosed with IUA or having at least one canceled transfer cycle due to a resistant thin endometrium (<7mm) on the endometrium transformation day, despite using of estradiol valerate combined with other adjuvant therapies, including aspirin, granulocyte colony-stimulating factor (G-CSF), vaginal sildenafil, etc.
Exclusion criteria
Exclusion criteria: (i) endometrial polyps, tuberculosis, dysplasia, or cancer; (ii) uterine malformations; (iii) accompanied by other diseases, including diabetes, lupus erthematosus, etc.; (iv) medical contraindications to HBO therapy, including ear injury and thoracic surgery, uncontrolled hypothermia, claustrophobia, etc.; (v) did not commence FET within 3 months after HBOT; (vi) did not want to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Endometrial thickness on the endometrium transformation day; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intrauterine clinical pregnancy rate;Biochemical pregnancy rate;Embryo implantation rate;Ongoing clinical pregnancy rate;Live birth rate;Ectopic pregnancy rate;Miscarriage rate;Multiple pregnancy rate; | — |
Countries
China
Contacts
Public ContactYanping Li
Xiangya Hospital, Central South University
Outcome results
None listed