the quality of emergence from anesthesia and postoperative cognitive function
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients who plan to undergo laparoscopic radical resection for colorectal cancer will be included according to the following criteria:(1)ASA grade II to III; (2) 65-80 years old; (3) Body Mass Index (BMI) 18 to 30 kg/m2; (4) operation time 2-5 hours.
Exclusion criteria
Exclusion criteria: (1) severe chronic lung disease such as acute respiratory distress syndrome, chronic obstructive pulmonary disease and respiratory failure; (2) severe cardiovascular disease, such as NYHA classification III or IV, acute coronary syndrome, cardiac arrhythmia; (3) severe hepatic and renal dysfunction; (4) severe mental illness; (5) contraindications to PEEP, such as high intracranial pressure, hypovolemic shock (6) patients themselves or their families refuse to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time to spontaneous respiration recovery ;time to extubation ;time to orientation ;RASS;Mini-mental State Examination(MMSE);heart rate (HR);mean arterial pressure (MAP);cerebral oxygen saturation(rSO2);optic nerve sheath diameter(ONSD);internal jugular vein valve function;time to emergence;Montreal Cognitive Assessment Scale (MOCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| operation time;anesthesia time;sex ratio;input and output;dosage of vasoactive drugs;PONV;Postoperative dizziness;blurred vision;american socity of Aneshesiologists physical status classification system(ASA);age; | — |
Countries
CHINA
Contacts
Nanjing hospital of T.C.M