Postoperative pulmonary complications
Conditions
Interventions
Sugammadex group:When the train-of-four stimulation (TOF) count reached 2, the sugammadex group was given sugammadex at a dosage of 2 mg/kg
Placebo group:When the train-of-four stimulation (TOF) count reached 2, the placebo group was given equal volume of normal saline.
Sponsors
Jiangsu Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1)aged 18-64 years with a BMI of 18-28 kg/m², American Society of Anesthesiologists (ASA) physical status of ?-? 2)scheduled for unilateral thoracoscopic lobectomy or segmentectomy 3)patients should fully know and understand the content of the consent form, and should be willing to sign the informed consent form
Exclusion criteria
Exclusion criteria: 1) allergy to sugammadex or other drugs 2) preoperative neuromuscular diseases 3) severe hepatic dysfunction (stage 4 kidney disease or higher); severe renal dysfunction (aspartate aminotransferase or alanine aminotransferase greater than twice the upper limit of institutional normal); severe heart disease (NYHA grade ? or ?) 4)preoperative pulmonary diseases such as COPD (except GOLD1 grade: FEV1 = 80% of the predicted value), asthma, pulmonary infection, and bronchiectasis 5)previous history of lung surgery 6) postoperative transfer to intensive care unit 7)participation in other clinical studies within 30 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time from the end of surgery to extubation; time from drug administration to recovery of the TOF ratio (TOFr) to 0.9;the TOF ratio immediately after extubation;the length of stay in PACU;time from the end of surgery to ambulation;static and dynamic numerical rating scale (NRS) score at 24 and 48 hours after surgery;postoperative nausea and vomiting; duration of the chest tube insertion;the length of postoperative hospital stay ;hospitalization expenses; | — |
Countries
China
Contacts
Public ContactLianbing Gu
Jiangsu Cancer Hospital
Outcome results
None listed