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Effect of Cognitive Prehabilitation on the Incidence of Postoperative Cognitive Dysfunction Among Older Adults Undergoing Cardiac Surgery ——A Randomized Clinical Trial

Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Cardiac Surgery —The Neurobics Randomized Clinical Trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072806
Enrollment
Unknown
Registered
2023-06-26
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-07-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Delirium

Interventions

Non exercise group:Routine care is done without cognitive exercise before surgery.
5-hour exercise group:Perform 1 hour of cognitive exercise each day for 5 days before surgery to achieve a total training time of 5 hours.
10-hour exercise group:Perform 1 hour of cognitive exercise in the morning and 1 hour in the evening each day for 5 days before surgery to achieve a total training time of 10 hours.

Sponsors

The Affiliated Hospital of Xuzhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) American Society of Anesthesiology (ASA) physical status (I-IV). (2) Age= 60 years old . (3) Undergo any of the following types of cardiac surgery under elective general anesthesia: coronary artery bypass graft with or without valve surgery (aortic and/or mitral); valve surgery; aortic surgery. (4) The surgical plan is at least 5 days after meeting the inclusion criteria.

Exclusion criteria

Exclusion criteria: (1) History of psychiatric diseases such as Parkinson's disease and Alzheimer's disease . (2) History of alcohol, psychotropic drugs and drug dependence . (3) Communication disorders and inability to understand the contents of the scale . (4) History of brain disease (such as cerebral infarction, cerebral hemorrhage) or recent history of seizures ( 6 years of education) MMSE < 24 . (6) Positive preoperative Confusion Assessment Method test (CAM) . (7) Active depression or as indicated by the Geriatric Depression Scale screening test (score = 10) . (8) involved in other studies.

Design outcomes

Primary

MeasureTime frame
incidence of delirium within 7 days after surgery;

Secondary

MeasureTime frame
Incidence of delayed neurocognitive recovery (7-30 days);Incidence of postoperative cognitive dysfunction (30 days to 1 year);the time of first onset of delirium and the duration and severity of delirium;Incidence of postoperative depression(GDS score);Postoperative recovery status (PQRS score);Postoperative pain score (NRS score);Extubation time;ICU hospitalization time;total hospitalization time;All-cause mortality at 1 year after surgery;

Countries

China

Contacts

Public ContactZhang Yueying

The Affiliated Hospital of Xuzhou Medical University

zyy0218@126.com+86 180 5226 8602

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026