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Site-specific microbiome in common lacrimal gland disorders

Site-specific microbiome in common lacrimal gland disorders

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300072796
Enrollment
Unknown
Registered
2023-06-25
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lacrimal gland disorders

Interventions

IgG4-related disease (IgG4ROD) cohort:Ocular examination, orbital imaging by computerized tomography, conjunctival swabs and stool for microbiome sampling
Lacrimal gland swelling (longitudinal) subjects:Ocular examination, orbital imaging by computerized tomography, conjunctival swabs and stool for microbiome sampling

Sponsors

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who have at least one lacrimal gland biopsied and with histological diagnoses of lacrimal gland inflammation (IOI, IgG4ROD, SS) or lymphoma

Exclusion criteria

Exclusion criteria: 1. Use of topical/systemic antibiotics in the past 3 months before microbiome sampling 2. Infection, surgery or radiotherapy to the site of sampling in the past 3 months

Design outcomes

Primary

MeasureTime frame
Conjunctival and gut microbiome signature in each group of lacrimal gland disorder;Correlation between the microbiome profile and treatment outcome;Correlation between the microbiome profile and extraorbital involvement in IgG4ROD;—

Countries

Hong Kong

Contacts

Public ContactDr Chong Kam Lung Kelvin

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong

chongkamlung@cuhk.edu.hk+852 3943 5805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026