breast cancer
Conditions
Interventions
Esmolol Treatment Group:Inject 0.3 mg/kg of esmolol intravenously 3 minutes before intubation, and continuously pump 50 ug/kg/min of esmolol during surgery until tracheal extubation
Control Group:Replacing Esmolol with Isophysiological Saline
Sponsors
Weihai Municipal Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: ? ASA grading I - II; ? BMI20~28kg/m2;? Patients who completed the anthracycline combined with paclitaxel regimen before surgery; ? Age 18-60 years old
Exclusion criteria
Exclusion criteria: ? Patients with bronchial asthma and severe chronic obstructive pulmonary disease; ? Long term use of analgesics and/or psychotropic drugs before surgery; ? Individuals who are allergic to anesthetic drugs; ? Those who cannot tolerate chemotherapy drugs; ? Patients with severe cardiovascular diseases (sinus bradycardia, first degree atrioventricular block, cardiogenic shock, heart failure); ? Severe liver and kidney function disorders; ? Pregnant or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hs-cTnT;CK-MB;LDH;NT-proBNP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Left Heart Function Assessment;hemodynamics;Adverse cardiac reactions; | — |
Countries
China
Contacts
Public ContactWang Xiaodong
Weihai Municipal Hospital
Outcome results
None listed