Sepsis
Conditions
Interventions
Intervention group:Vitamin C combined Vitamin B1
Control group:Normal saline
Sponsors
The Sixth Medical Center of PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.over 18 years old and signed informed consent 2.Fit the diagnostic criteria of Sepsis 3.0. For ICU infections or suspected infections, SOFA scores increase over 2 points compared with baseline. For non-ICU infections or suspected infections, qSOFA scores are over 2 points. All included patients should be admitted within 12 hours after diagnosis of sepsis.
Exclusion criteria
Exclusion criteria: Included patients are excluded if they met any of the following criteria. 1.Pregnant or lactating women. 2.Unable to remove the source of infection. 3.A known history of radiation or chemotherapy. 4.Known of end-stage diseases, immunodeficiency diseases, agranulocytosis, long tern use of hormones over physiological replacement doses, history of organ or bone marrow transplantation, hemochromatosis, glucose-6-phosphate dehydrogenase deficiency, kidney stones, oxalate disorders, gout, cysteinuria, sideroblastic anemia or thalassemia, sickle cell anemia. 5.Known of refuse or inability to comply with test protocol for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day all-cause mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of use of vasoactive drugs;Length of ICU stay;Duration of mechanical ventilation;SOFA scores change in 72 hours;ICU mortality rate;Hospital mortality rate;ICU hospitalization cost; | — |
Countries
China
Contacts
Public ContactLi Qi
The Sixth Medical Center of PLA General Hospital
Outcome results
None listed