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Study on the effect and mechanism of the enhanced external counterpulsation on cognitive impairment after ischemic stroke based on multimodal MRI

Study on the effect and mechanism of the enhanced external counterpulsation on cognitive impairment after ischemic stroke based on multimodal MRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300072747
Enrollment
Unknown
Registered
2023-06-25
Start date
2023-07-01
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitive impairment after ischemic stroke

Interventions

control group:no
intervention group:enhanced external counterpulsation

Sponsors

The First People’s Hospital of Jingzhou
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria for ischemic stroke and post stroke cognitive impairment. 2. First stroke with unilateral lesion. 3.Age 18-80 years old,gender is not limited. 4. Stable vital signs. 5.MoCA score<26. 6.Volunteer to sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1.Unstable vital signs. 2. Severe heart and lung diseases (such as moderate to severe heart valve disease, moderate to severe pulmonary hypertension, decompensated heart failure, etc.), multiple organ failure, malignant tumors, severe Mental disorder, etc. 3. Lower limb venous thrombosis, active thrombophlebitis. 4. Various hemorrhagic diseases or obvious bleeding tendencies. 5. Arrhythmias that may interfere with the electrocardiogram function of EECP device. 6. Pre stroke cognitive impairment, such as Alzheimer's disease, Parkinson's disease, dementia and Mild cognitive impairment. 7. Cognitive impairment caused by other reasons, such as alcohol and drug abuse. 8. Unable to cooperate due to other reasons.

Design outcomes

Primary

MeasureTime frame
Montreal Cognitive Assessment(MoCA);

Secondary

MeasureTime frame
Mini-Mental State Examination(MMSE);Stroop Color Word Test;Trail Marking Test(TMT);Symbol Digit Modalities Test(SDMT);Functional magnetic resonance imaging(fMRI);structural MRI(sMRI);Diffusion Tensor Imaging(DTI);Modified Barthel Index(MBI);

Countries

China

Contacts

Public ContactLiu Wulong

The First People’s Hospital of Jingzhou

543606830@qq.com+86 181 6313 5098

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026