vtiligo
Conditions
Interventions
Combination therapy group:JAK inhibitors 1-2 tablets / d, NB-UVB 3 times a week
Phototherapy only group:NB-UVB 3 times a week
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.The definitive diagnosis of vitiligo in this study was based on standard guidelines proposed by the British Association of Dermatologists; 2.Male or female, with 18–60 years old; 3.Patients with poor efficacy of routine treatments such as oral glucocorticoids or phototherapy given systematically; 4.No systemic treatments or phototherapy in the past 4 weeks; 5.Informed and agreed to participate in this study;
Exclusion criteria
Exclusion criteria: 1.hypertension or severe or acute heart failure; 2.infection, such as upper respiratory tract infection, active tuberculosis, Hepatitis B virus infection, urinary tract infection, HIV infection, or other types of infection; 3.liver or kidney dysfunction; 4.cancer; 5.autoimmune diseases, specifically diabetes, Addison's disease, or systemic lupus erythematosus; 6.pregnant or breast-feeding; 7.coagulation function abnormalities; 8.unwilling to attend follow-up visits.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T-VASI 50%; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean percentage change from baseline in T-VASI ;Response rate; | — |
Countries
China
Contacts
Public ContactTao Wang
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union
Outcome results
None listed