Analgesics-sedatives
Conditions
Interventions
Experimental group (Fospropofol group):Fospropofol group : loading dose 1-3mg/kg, Maintenance dose 1-4mg/kg/h
Control group (Midazolam group):Midazolam group : loading dose 0.01-0.05mg/kg, Maintenance dose 0.02-0.1mg/kg/h
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1)Age = 18 years old; (2)Patients admitted to ICU requiring sedation; (3)Obtain informed consent from the patient or family.
Exclusion criteria
Exclusion criteria: (1)Age< 18 years old; (2)Long-term use of benzodiazepines or psychotropic drugs; (3)Presence of severe craniocerebral injury, brain tumor, increased intracranial pressure, cerebrovascular accident, coma, persistent status epilepticus, etc; (4)Any condition that prevents the correct assessment of cognitive function, such as language and sensory impairment or psychiatric disorders (language difficulties or psycho-organic dysfunction); (5)Patients with allergies to test-related drugs; (6)Participation in other exploratory clinical trials within 6 months prior to screening; (7)Unable to obtain informed consent or authorization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to achieve target sedation after administration of test drug; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation;Remediation rates requiring other drugs in combination with sedation;ICU hospitalization time;Total hospitalization time; | — |
Countries
China
Contacts
Public Contactxiufen yang
The First Hospital of Hebei Medical University
Outcome results
None listed