Knee arthritis and total knee arthroplasty
Conditions
Interventions
HBO Group:Hyperbaric Oxygen Therapy administered after Total Knee Arthroplasty.
Control Group:Normobaric Oxygen Therapy administered after Total Knee Arthroplasty.
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for osteoarthritis of the knee and have surgical indications; (2) The patient has no past history of open trauma, fracture, or surgery on both knees; (3) Other factors causing knee symptoms and mobility impairment, such as lumbar disc herniation and lumbar spinal stenosis, are excluded; (4) Only undergoing initial unilateral Total Knee Arthroplasty (TKA) due to knee osteoarthritis. No patellar replacement was performed during the operation, and all cases underwent patellar reshaping; (5) Age between 40-75 years old, no restrictions on the side of replacement, gender is not limited; (6) Have not taken steroids and anticoagulant therapy before surgery; (7) Preoperative tests and examinations are passed; (8) The patient and their family members are willing to participate in this research study, and have signed an informed consent form preoperatively.
Exclusion criteria
Exclusion criteria: (1) Those who have a history of blood system diseases, with bleeding tendencies accompanied by coagulation disorders; (2) Those who have had excessive blood loss during the operation and received blood transfusions postoperatively; (3) Those with severe heart, brain, liver, lung, and kidney diseases, who cannot tolerate surgery and hyperbaric oxygen treatment; (4) Those with a history of mental disorders and neuromuscular system diseases; (5) Those who cannot tolerate surgery and hyperbaric oxygen treatment due to malignant tumors or other diseases; (6) Those with a history of lower limb deep vein thrombosis, uncontrolled knee joint infection, knee tuberculosis, etc.; (7) Those who refuse to participate in this research study or refuse to sign the treatment consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammation markers (C-reactive protein, interleukin-6, erythrocyte sedimentation rate);creatine kinase;Myoglobin;lactate dehydrogenase;Glutamic Oxaloacetic Transaminase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Circumference of the Operative side limb;visual analogue scale;Hemoglobin, hematocrit, and albumin;Knee range of motion on the operated side; | — |
Countries
China
Contacts
Public ContactXiaojun Shi
West China Hospital, Sichuan University
Outcome results
None listed