A multi-center, randomized, double-blind, sham-stimulation controlled study of transcranial magnetic stimulation with precision navigation for the treatment of Multiple System Atrophy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300072658

Enrollment

Unknown

Registered

2023-06-20

Start date

2023-06-28

Completion date

Unknown

Last updated

2023-10-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple System Atrophy

Interventions

MSA-P Intervention group:iTBS

MSA-P Control group:sham stimulation

MSA-C Intervention group:cTBS

MSA-C Control group:sham stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Meet the diagnostic criteria of clinically confirmed and probable MSA proposed by MDS in 2022, and confirmed by doctors engaged in Parkinson 's disease and dyskinesia for more than 5 years; 2. The recall of medical history is detailed and reliable; 3. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Suffering from other chronic degenerative diseases of the nervous system; 2. Patients with other diseases and serious complications; 3. Other causes of limb movement disorders or affect the assessment of the condition; 4. TMS treatment contraindications, related to the disease: a. history of epilepsy; b. traumatic brain injury, brain tumors, encephalitis, cerebrovascular disease, cerebral metabolic diseases; c. taking drugs can reduce the seizure threshold, not taking anticonvulsant drugs and prevent seizures; d. sleep deprivation, jet lag did not recover, drunkenness, excessive fatigue. Increased risk and uncertain factors: a. intracranial implantation of electrodes; B. pregnancy; c. severe or recent heart disease. 5. MRI contraindications for patients, such as metal implants in the body, unable to cooperate with the examination.

Design outcomes

Primary

Measure	Time frame
the Unified Multiple System Atrophy Rating Scale total score;	—

Secondary

Measure	Time frame
the UPDRSIII score ;Icars score;electroencephalogram;functional magnetic resonance imaging;MEP;gait quantitative analysis;berg balance scale;COMPASS-31 score;HAMA;HAMD;MMSE;	—

Countries

China

Contacts

Public ContactLiu Xuedong

Department of Neurology, Xijing Hospital, The Air Force Military Medical University, Xi'an, China.

dongxg0752@163.com+86 138 9195 1606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026