Central nervous system infection
Conditions
Interventions
Gold Standard:Using cerebrospinal fluid co culture, PCR, antigen detection combined with pathogenic indicators as the gold standard
Index test:Multiplex polymerase chain reaction, Targeted Next-generation Sequencing, metagenomics next generation sequencing
Sponsors
Beijing Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: ? Age: 29 days to 18 years old; ? All enrolled children met the modified version of World Health Organization (WHO) classification criteria for bacterial meningitis surveillance cases or the criteria for suspected encephalitis cases
Exclusion criteria
Exclusion criteria: ? cases of autoimmune encephalitis; ? tumors with central nervous system involvement; ? cases with bloody cerebrospinal fluid; ? the volume of cerebrospinal fluid was less than 1ml; ? Children refused to be enrolled for various reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pathogen detection rate;The incidence of neurological complications;GOS score at discharge;Sensitivity;specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total length of hospitalization;Duration of pathogen diagnosis;Antibiotic usage; | — |
Countries
China
Contacts
Public ContactLiu Gang
Beijing Children's Hospital
Outcome results
None listed