Stroke
Conditions
Interventions
Association group:Routine rehabilitation training +rTMS intervention + cognitive-motor dual task training
CMDT group:Routine rehabilitation training + fake rTMS intervention + cognitive-motor dual task training
control group:Routine rehabilitation training
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria (all of the following criteria were met for inclusion):?meeting the diagnostic criteria for stroke in the Diagnostic Key Points for Various Major Cerebrovascular Diseases in China 2019 and confirmed by cranial CT or MRI;?unilateral stroke with upper limb hemiparesis, first stroke, stroke duration 14 days to 6 months after stroke onset in patients in the subacute phase of stroke;?age 30-70 years;?right-handedness. ? able to reach, grasp and lift objects with the hemiplegic side hand;?presence of mild cognitive impairment with Montreal Cognitive Assessment (MoCA) <26 and =10;?able to follow study instructions;?good cardiopulmonary function for aerobic exercise;?able to remain in a seated position for at least 30 minutes;?voluntary participation in this study and informed consent signed by the person or signed by his/her immediate family on his/her behalf.
Exclusion criteria
Exclusion criteria: Exclusion criteria (if one of the following criteria is met, the patient cannot be enrolled): ?transcranial surgery or cranial defect; ? installation of metal or pacemaker implants; ?people with or suspected of having cognitive impairment before the onset of the disease; ? previous history of brain tumor, traumatic brain injury, seizure, or risk of seizure; ? people with psychiatric disease or delirium state affecting cognitive examination; ? people with severe speech, vision, or hearing impairment that cannot cooperate; ? people with combined severe cardiovascular and liver and kidney function diseases; and patients with severe infection and end-stage tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Fugl-Meyer Assessment for upper extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Minimum Mental State Examination;Trail Making Test A and B;digit span test;Action ResearchArm Test;Box and Block Test;Hand grip strength test;Modified Barthel Index; | — |
Countries
China
Contacts
Public ContactJie Jia
Huashan Hospital, Fudan University
Outcome results
None listed