Postoperative delirium
Conditions
Interventions
Rimazolam sedation group (Group R):In group R, rimazolam 0.1mg/kg was given after plane fixation, followed by 5µg/kg/min continuous pumping until the BIS dropped to 75, then the infusion rate was grad
Sponsors
Dalian Municiple Center Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 95 Years
Inclusion criteria
Inclusion criteria: All sexes, age > 60 years, ASA Class I- III; patients undergoing elective lower limb orthopaedic surgery; patients who have signed the informed consent and subject declaration
Exclusion criteria
Exclusion criteria: Patient or family refusal to participate in the experiment; contraindications to combined lumbar and rigid anaesthesia (i.e. coagulation disorders, puncture site infection and refusal of combined lumbar and rigid anaesthesia); history of traumatic brain injury and brain surgery, preoperative history of schizophrenia, epilepsy, Parkinson's, myasthenia gravis; combined severe anaemia, history of psychotropic drug or alcohol abuse; combined severe cardiac insufficiency (left ventricular ejection fraction EF 1000ml, allergic to anaesthetic drugs, poor perioperative blood transfusion and anaesthesia; patients or family members with poor compliance; patients who have changed their treatment plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium;Perioperative blood pressure;Perioperative heart rate;SPO2;Consumption of atropine; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;MMSE score;Consumption of norepinephrine; | — |
Countries
China
Contacts
Public ContactCongjie Bi
Dalian Municiple Center Hospital
Outcome results
None listed